Alyssa Barry

Research project description:
Every thirty seconds a child dies from malaria in the developing world. The disease is curable by drug treatment but access to affordable healthcare and widespread drug resistance is a problem for the majority of people at risk of infection. An effective malaria vaccine would be a sustainable approach to controlling malaria in these settings.

Malaria is caused by a tiny parasite transmitted from person to person by the female anopheline mosquito. Following a short period of time in the liver, it is released into the bloodstream where it hides and multiplies inside red blood cells. To communicate with the outside world, the parasite coats the red blood cell with a protein known as PfEMP1. This makes it a target for developing antibodies, so the parasite regularly switches to a new coat. The parasite has an arsenal of up to 60 var genes that encode different PfEMP1 – so effectively 60 different coats. Each malaria parasite has a unique set of var genes. In the context of a malaria endemic area such as a village in Africa or Papua New Guinea, this results in an enormous potential for people to be infected repeatedly and for long periods of time and more than once. But, after many infections people develop immunity to the disease. This is thought to be associated with the acquisition of antibodies to all of the var genes in a population. If a child makes it to the age of five or so, they will likely be protected. Development of a vaccine that replicates this immunity is a high priority.

Alyssa’s research aims to understand var gene diversity; how var genes evolve; and the development of immunity to the multitude of var genes within populations. She will develop genomic tools for the surveillance of malaria parasite genomes and host immune responses. The ultimate goal of this research is a blueprint for a malaria vaccine that mimics the natural exposure to the malaria parasite in endemic areas.

• Now a Laboratory Head at Walter & Eliza Hall Institute of Medical Research
• NIH International Centre for Excellence in Malaria Research (Collaborator): Research to Control and Eliminate Malaria in SE Asia and SW Pacific
• Awarded a NHMRC Howard Florey Centenary Fellowship