Masters receives Milstein Young Investigator Award

26 October
Seth Masters with his partner and fellow WEHI researcher Lisa Mielke and fellow WEHI researcher Melissa Call
Seth Masters with his partner and fellow WEHI researcher Lisa Mielke and fellow WEHI researcher Melissa Call

veski innovation fellow Dr Seth Masters from the Walter & Eliza Hall Institute has received one of five Milstein Young Investigator Awards. 

The Milstein Young Investigator Awards are bestowed upon individuals who have made an impact on interferon and cytokine research early in their careers. 

Dr Masters completed his PhD at WEHI, which resulted in the first structure of the SPRY/B30.2 domain. 

In 2006, Dr Masters started his postdoctoral studies with Dan Kastner at the NIH who previously discovered mutations in the SPRY/B30.2 domain of the protein Pyrin, which cause familial Mediterranean fever. During this postdoc he was part of a team that discovered a new inflammatory disease caused by mutations affecting the IL-1 receptor antagonist (IL-1Ra). 

Starting in 2009, Dr Masters completed a second postdoc at Trinity College Dublin where he continued to work on IL-1. Research here showed that soluble oligomers of IAPP, which are increased in type 2 diabetes, trigger the NLRP3 inflammasome to process IL-1b, which impairs the function of insulin producing beta cells. 

With the support of veski, Dr Masters has now started his own laboratory in the newly formed Inflammation Division at WEHI, and has published on miRNA regulation of the NLRP3 inflammasome and the first mouse models of NLRP1 inflammasome modulation.

The awards were presented at the 2014 meeting of the International Cytokine and Interferon Society to be held at the Melbourne Convention & Exhibition Centre in Melbourne, Australia, 26-29 October.

International Cytokine and Interferon Society  (ICIS) members who attend the Annual Meeting of the ICIS and who have received a PhD or medical degree within the previous 8 years were eligible. 

This award is provided by a generous gift of the Milstein Family.

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